Continuous low doses of far ultraviolet C (far-UVC) light kills airborne flu viruses without harming human tissues, causing skin cancers or cataracts.
The findings could pave the way to installing the overhead lamps in hospitals, surgeries, schools and airports to help stop seasonal epidemics.
The results, led by Columbia University, come amid the worst flu outbreak in recent years in the US, with every state except rocked by the virus.
And the deadly outbreak has claimed the lives of more than 200 people in the UK, but appears to be slowing down as the end of season approaches.
Scientists, led by Professor David Brenner, conducted the new trial on the H1N1 virus - the same strain that killed 50 million in the 1918 Spanish flu pandemic.
But, in theory, far-UVC light could also kill the H3N2 strain, dubbed 'Aussie flu', which has sparked widespread fears of a similar pandemic this winter.
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