Nicotine is the active part of tobacco which most scientists think is to blame for both the stimulating and addictive effects of cigarette smoking.
Despite widespread efforts by US regulators and the World Health Organization to stem the sale of cigarettes and their devastating public health consequences, smoking kills 480,000 Americans every year.
The FDA first announced its intent to regulate nicotine levels in 2009, but the formal notice, published on Thursday, marks the first real action the agency has been able to take after spending years hamstrung by Big Tobacco's legal challenges.
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