At-risk patients, discovered via a saliva test, may be able to avoid dementia if they take a low-dose of the painkiller from middle age for the rest of their lives, they add.
Ibuprofen is thought to dampen inflammation in the brain, which leads to the death of nerve cells and is associated with Alzheimer's.
Lead author Dr Patrick McGeer, from the University of British Columbia, said: 'Individuals can prevent that from happening through a simple solution that requires no prescription or visit to a doctor.
'This is a true breakthrough since it points in a direction where Alzheimer's can eventually be eliminated. If it is applied worldwide, Alzheimer's would disappear. Our discovery is a game changer.'
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